Silly girl, it's Janis Joplin! :p

Diva Destruction ("You Are My Sickness" is one of my fave songs ever!)

I second:

-Garbage (Shirley Manson is amazing, the lyrics are so provocative)
-Rasputina (One of my favourite bands, so creative and original. There's something incredibly magical about their music.)
-Siouxsie and the Banchees (of course!)
-Jack Off Jill (Check out their cover of Love Song by The Cure. It's very cool!)
-Theatre of Tragedy
-Nightwish
-Cocteau Twins
-Evanescence (I admit, I'm a huge fan.)
-Kidney Theives
-Inkubus Sukkubus (sp?)

I can't believe I forgot Inkubus Sukkubus!

Also, if you're into metal, check out Jucifer

I was waiting for that. Check them out, Brody Dalle is a great singer. They're definitely up there on my list.

And of course don't forget the classic band, Heart.

Also, if you are searching for Goth in particular, check out The Missing. They're moreso underground, so you might have a hard time finding their music anywhere besides buying their CDs online. Really good band anyway. Website: http://www.themissing.com/

Didn't you know, Freaky? I reserve the right to make spelling mistakes at any and all times. ;P

I can't believe I left off some of my favorite bands off my list!

- The Cranes
- Portishead
- Love Spirals Downwards
- Emily Autumn
- Android Lust

I'm so ashamed.

Tori Amos! :p
Ill try and avoid ones that have already been mentioned :
The Creatures
Hole
Veruca Salt
Skindive
Moth Complex
Skunk Anansie
Skin
Sleater-Kinney
Snake River Conspiracy
The Breeders
Sneaker Pimps (Their first album is the only one with female vocals "Becoming X")
Sons & Daughters
Stina Nordenstam
P.J. Harvey
The Wannadies (Both male & female singers)
The Yeah, Yeah, Yeahs
Atari Teenage Riot (Both Male & Female Vocalists)
Melissa Auf Der Maur
Linda Strawberry
The Birthday Massacre
Black Tape For A Blue Girl (Both Male & Female Singers)
Charolotte Hatherly
The Cranberries
Drugstore
Elastica

hmm, a lot of my favourites have gone (Blondie, Portishead, Siouxsie, Elastica etc). Some I didn't see:

Billie Holiday - her version of Gloomy Sunday is the best in my opinion
Blood & Roses - Deathrock
The Bug (Featuring Warrior Queen) - Ragga
The Concretes - a beautiful sounding Swedish band
Daisy Chainsaw - Punk
Die Form - Industrial
The Fugees (male and female) - Hip-Hop
Gitane Demone - Deathrock
The GO! Team - Chant/Hip-Hop/Funk
Kirlian Camera - Industrial
Lauryn Hil - Hip-Hop and Soul
Massive Attack (male and female) - Trip-Hop
Mz O and Her Guns - Eva O's recent band
Nouvelle Vague - a French Bossa Nova covers bands
Patti Smith - erm...Rock?
Peaches - Electroclash
Penis Flytrap - Deathrock
Pilori - Darkwave
Pretenders - Rock
Pretty Girls Make Graves - 'Indie'
Pzychobitch - Industrial
Rainer Maria - Post-Emo
Republica - Pop/Rock
Rubella Ballet - Anarcho-Punk
Sara Noxx - Darkwave
Scarling - Shoegazing
Skeletal Family - Deathrock
The Velvet Underground & Nico - Amazing :p
Voodoo Church - Deathrock
Xmal Deutschland - Goth Rock
Zero 7 (normally feature female vocals) - Downtempo, Trip-Hop etc

hmmm, probably missed a few. Oh, and when I say 'Industrial' above, I mean it in the broad sense.

Hole
Blondie
Metric
Hedwig and the angry inch(its a movie but you can get the songs. Its really a guy singing but its soooo awesome)
Be your own pet
Alanis Morissette
Ani Difranco
Dionne Warwick
Fleetwood Mac
Jefferson Airplane(Grace slick is AMAZING)
Garbage
Controller Controller
Kelly Osbourne
Bikini Kill
No Doubt
Pink
Mellisa Oftimar
The Cardigans
The Cranberrys
Tori Amos
Bif Naked
Babes in toyland

Its actually : Melissa Auf Der Maur.
And I totally forgot about Ani Difranco, she has some amazing lyrics.

Since this is somewhat related:

I'm looking for a certain band with a female lead singer, I was flipping through channels and saw this band on Fuse (I know, I know), they sounded pretty good but I still don't know their name.

All I know is that they sounded like they were Gothic Metal and had a female lead singer who was African American (Don't want to offend anybody).

If anybody has any information, could you please let me know.

Joanna Newsom
Regina Spektor
Yeah Yeah Yeahs

There is this band called Psideralica here is a few clips on youtube, the best is called "This is my life".

http://www.youtube.com/watch?v=MzOnmAlrgzo

No mention of Black Tape for a Blue Girl? Male and female vocals, all of which are lovely...

Album suggestion:"This Lush Garden Within"

Not the most specific request, but I suppose I`ll put down who I've been listening to a lot lately:

Diamanda Galas(my number 1 recommendation.... dark, haunting and utterly frightening vocal experimentation. Get The Divine Punishment and any of her other early studio albums)

Siouxsie & the Banshees(of course, and they`ve probably been recommended 500 times already)
Cocteau Twins(same as above)
Dead Can Dance(ditto)
Faith & the Muse(excellent act who combine traditional gothic rock with medieval influences)
Chaostar(new band from Greece who combine experimental symphonics, operatic vocals, and choirs)
Arcana(beautiful medieval ethereal melodies and ambient soundscapes, their new one is more of a middle eastern ambient album though, with no vocals and lots of percussion)
Dark Sanctuary(dark and atmospheric ethereal ambience)
Gate(folkish medieval hard rock from Norway)
Epica(to tell the truth, their gothic metal stuff didn`t impress me at all, but their new album is an enbtirely symphonic film score)
Bloodflowerz(gothic metal, but a hell of a lot better than commercial crap like Lacuna Coil)
Third & the Mortal(experimental atmospheric Norwegian band)
Ataraxia(beautiful operatic music from Italy)

there`s loads more, but that`s what I`ve been hearing lately, I`ll probably add more later on

The only good ones I know are:
My Ruin
Kidneythieves
Kittie
Paramore
Lacuna Coil
Opeth (or Otep, I get really confused with those)
Crisis
Arch Enemy

And that's it, pretty much.

Definatley Otep if your thinking female vocals.